Pyridines and derivatives
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Filtered Search Results
Selleck Chemical LLC Tolinapant
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Tolinapant (ASTX660) is a potent non-peptidomimetic antagonist of cIAP1/2 and XIAP that inhibits the interactions between a SMAC-derived peptide and the BIR3 domains of XIAP (BIR3-XIAP) and cIAP1 (BIR3-cIAP1) with IC50 values less than 40 and 12 nmol/L respectively
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Selleck Chemical LLC GSK1070916 S2740-5mg
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GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3 5 nM/6 5 nM It displays 100-fold selectivity against the closely related Aurora A-TPX2 complex Phase 1
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Selleck Chemical LLC JTC-801 S2722-5mg
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JTC-801 is a selective opioid receptor-like1 (ORL1) receptor antagonist with IC50 of 94 nM weakly inhibits receptors and
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Selleck Chemical LLC Icotinib (BPI-2009H) S2922-5mg
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Icotinib (BPI-2009H) is a potent and specific EGFR inhibitor with IC50 of 5 nM including the EGFR EGFR(L858R) EGFR(L861Q) EGFR(T790M) and EGFR(T790M L858R)
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TARGETMOL CHEMICALS INC Mavatrep 5MG
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Also available in 1 mL, 1 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Mavatrep (JNJ-39439335) is a selective antagonist of TRPV1 with Ki of 6.5 nM and can be used for studies about inflammatory pain. Purity 98.38%
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TARGETMOL CHEMICALS INC MRE3008F20 5MG
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Also available in 1 mg, 2 mg, 10 mg, 25 mg, 50 mg and bulk. Please contact Fisher for quotes. MRE3008F20 is a species-selective and potent adenosine A3 receptor (AA3R) antagonist that inhibits Cl-IB-MECA-induced cAMP production and can be used in glaucoma and asthma studies.13483-88-88-9 Purity 97.66%
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Selleck Chemical LLC PD153035
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PD153035 is a specific and potent inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase (Ki 5 2 pM)
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Chemscene ChemScene | 2,4-Dibromo-5-fluoropyridine | 250MG | CS-0157808 | 0.98 | 1256805-06-7| MFCD11114541 | 254.88
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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ChemScene | 2,4-Dibromo-5-fluoropyridine | 250MG | CS-0157808 | 0.98 | 1256805-06-7| MFCD11114541 | 254.88
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Selleck Chemical LLC ML355
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ML355 is a potent and selective inhibitor of human 12-Lipoxygenase with an IC50 of 290 nM and shows excellent selectivity over related lipoxygenases and cyclooxygenases
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Medchemexpress LLC GSK481 | 1622849-58-4 | 98.0% | 377.39 | C21H19N3O4 | 50 MG
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GSK481 is a potent, selective inhibitor of receptor-interacting protein 1 (RIP1) kinase for biochemical and cellular research. It inhibits RIP1 autophosphorylation (Ser166) with low-nanomolar potency and shows cellular activity in U937 assays. Documented physicochemical properties, solubility data, and storage recommendations support its use in both in vitro and in vivo experiments.
- Potent RIP1 kinase inhibition with low-nanomolar biochemical activity.
- Demonstrated cellular activity in immune-relevant cell assays.
- Useful for studies of necroptosis and RIPK1-mediated signaling.
- Documented solubility in DMSO and multiple in vivo vehicle systems.
- Long-term powder stability with recommended storage conditions.
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Selleck Chemical LLC FIIN-2
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FIIN-2 is an irreversible pan-FGFR inhibitor with IC50 of 3 09 nM 4 3 nM 27 nM and 45 3 nM for FGFR1/2/3/4 respectively
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Selleck Chemical LLC Amisulpride S1280-1g
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Amisulpride (DAN-2163) is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder
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Selleck Chemical LLC Osunprotafib-E1207-5MG
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Osunprotafib is a potent PTPN1 or PTPN2 inhibitor with a sub-nanomolar activity
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Cayman Chemical U18666A Inhibitors
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A cell permeable drug that inhibits cholesterol trafficking from late endosomes/lysosomes to the ER, but not to the plasma membrane
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Selleck Chemical LLC U73122
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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U73122 is a potent phospholipase C (PLC) inhibitor which reduces agonist-induced Ca2 increases in platelets and PMN U73122 potently inhibits human 5-lipoxygenase (5-LO)
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